IGF2 signaling and regulation in cancer

Cytokine Growth Factor Rev. 2015 Jun;26(3):371-7. doi: 10.1016/j.cytogfr.2015.01.002. Epub 2015 Feb 4.

Abstract

Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpression is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is developmentally regulated; however, malignant tissues are characterized by re-activation of the fetal IGF2 promoters, especially P3. In this review, we describe the mechanisms of IGF2 signaling and regulation in normal and malignant tissues and their clinical implications.

Keywords: Cancer; Chemoresistance; IGF2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Resistance, Neoplasm / physiology
  • Humans
  • Insulin-Like Growth Factor II / chemistry
  • Insulin-Like Growth Factor II / genetics
  • Insulin-Like Growth Factor II / metabolism*
  • Neoplasms / metabolism*
  • Signal Transduction

Substances

  • Insulin-Like Growth Factor II