Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases

Cell Biochem Biophys. 2015 Jun;72(2):485-94. doi: 10.1007/s12013-014-0492-5.

Abstract

Cardiovascular diseases remain one of the major health problems worldwide. The worldwide research against cardiovascular diseases as well as genome wide association studies were successful in indentifying the loci associated with this prominent life-threatening disease but still a substantial amount of casualty remains unexplained. Over the last decade, the thorough understanding of molecular and biochemical mechanisms of cardiac disorders lead to the knowledge of various mechanisms of action of polyphenols to target inflammation during cardiac disorders. The present review article summarizes major mechanisms of polyphenols against cardiovascular diseases.

Keywords: Cardiovascular diseases; Polyphenols; Redox signaling.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / metabolism*
  • Humans
  • NF-kappa B / metabolism
  • Oxidative Stress / drug effects*
  • Polyphenols / pharmacology*
  • Reactive Oxygen Species / metabolism
  • Signal Transduction / drug effects*

Substances

  • NF-kappa B
  • Polyphenols
  • Reactive Oxygen Species