Architectural plan of transcriptional regulation in Mycobacterium tuberculosis

Priyanka Baloni; Nagasuma Chandra

doi:10.1016/j.tim.2015.02.002

Architectural plan of transcriptional regulation in Mycobacterium tuberculosis

Trends Microbiol. 2015 Mar;23(3):123-5. doi: 10.1016/j.tim.2015.02.002. Epub 2015 Feb 17.

Authors

Priyanka Baloni¹, Nagasuma Chandra²

Affiliations

¹ Department of Biochemistry, Indian Institute of Science, Bangalore, 560012 India.
² Department of Biochemistry, Indian Institute of Science, Bangalore, 560012 India. Electronic address: nchandra@biochem.iisc.ernet.in.

PMID: 25701110
DOI: 10.1016/j.tim.2015.02.002

Abstract

Transcriptional regulation enables adaptation in bacteria. Typically, only a few transcriptional events are well understood, leaving many others unidentified. The recent genome-wide identification of transcription factor binding sites in Mycobacterium tuberculosis has changed this by deciphering a molecular road-map of transcriptional control, indicating active events and their immediate downstream effects.

Keywords: DNA-binding events; gene regulatory network; molecular road-map; transcriptional control.

Publication types

Comment

MeSH terms

Bacterial Proteins / chemistry*
DNA, Bacterial / chemistry*
DNA-Binding Proteins / chemistry*
Gene Expression Regulation, Bacterial*
Mycobacterium tuberculosis / chemistry*

Substances

Bacterial Proteins
DNA, Bacterial
DNA-Binding Proteins