Lessons learned about prostatic transformation from the age-related methylation of 5α-reductase type 2 gene

Am J Pathol. 2015 Mar;185(3):614-6. doi: 10.1016/j.ajpath.2015.01.001. Epub 2015 Feb 17.

Abstract

This commentary highlights the article by Ge et al, which proposes the use of methylation and expression of SRD5A2 as a gene signature to tailor therapies for prostatic diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism*
  • Aging / metabolism*
  • Animals
  • DNA (Cytosine-5-)-Methyltransferases / metabolism*
  • Humans
  • Male
  • Membrane Proteins / metabolism*
  • Prostate / metabolism*
  • Prostatic Hyperplasia / metabolism*

Substances

  • Membrane Proteins
  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
  • DNA (Cytosine-5-)-Methyltransferases