Mouse models of glioma

Stanley S Stylli; Rodney B Luwor; Thomas M B Ware; Fiona Tan; Andrew H Kaye

doi:10.1016/j.jocn.2014.10.013

Mouse models of glioma

J Clin Neurosci. 2015 Apr;22(4):619-26. doi: 10.1016/j.jocn.2014.10.013. Epub 2015 Feb 16.

Authors

Stanley S Stylli¹, Rodney B Luwor², Thomas M B Ware², Fiona Tan², Andrew H Kaye³

Affiliations

¹ Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia. Electronic address: stanley.stylli@mh.org.au.
² Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia.
³ Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.

PMID: 25698543
DOI: 10.1016/j.jocn.2014.10.013

Abstract

Gliomas are the most common primary tumour in the central nervous system in adults. The pathological hallmark of gliomas is their propensity for extensive infiltration into the surrounding brain parenchyma which results in tumour recurrence. Despite the use of optimal surgical removal and adjuvant therapies the most aggressive of these tumours, glioblastoma multiforme, has a poor patient prognosis, with median survival of less than 15 months. In this review, we discuss mouse glioma models that have been utilised to advance our basic knowledge of the processes involved in gliomagenesis and their use in the testing of novel therapies and treatment regimens in the preclinical setting.

Keywords: Brain tumour; Glioma; Mouse model; Therapy.

Publication types

Review

MeSH terms

Animals
Brain Neoplasms / chemically induced
Brain Neoplasms / pathology*
Brain Neoplasms / therapy
Disease Models, Animal
Glioma / chemically induced
Glioma / pathology*
Glioma / therapy
Mice