Abstract
TRPA1 and TRPV1 are ion channels crucial for pain sensation. In this issue of Neuron, Weng et al. (2015) demonstrate that the activity of TRPA1-TRPV1 heteromers is governed by Tmem100 and that disabling Tmem100 may be a novel pharmacologic strategy to combat pain.
Copyright © 2015 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Humans
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Male
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Membrane Proteins / metabolism*
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Pain / metabolism*
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TRPA1 Cation Channel
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TRPV Cation Channels / metabolism*
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Transient Receptor Potential Channels / metabolism*
Substances
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Membrane Proteins
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TRPA1 Cation Channel
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TRPV Cation Channels
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TRPV1 protein, mouse
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Tmem100 protein, mouse
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Transient Receptor Potential Channels
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Trpa1 protein, mouse