Loosening pain's grip by tightening TRPV1-TRPA1 interactions

Neuron. 2015 Feb 18;85(4):661-3. doi: 10.1016/j.neuron.2015.02.004.

Abstract

TRPA1 and TRPV1 are ion channels crucial for pain sensation. In this issue of Neuron, Weng et al. (2015) demonstrate that the activity of TRPA1-TRPV1 heteromers is governed by Tmem100 and that disabling Tmem100 may be a novel pharmacologic strategy to combat pain.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Male
  • Membrane Proteins / metabolism*
  • Pain / metabolism*
  • TRPA1 Cation Channel
  • TRPV Cation Channels / metabolism*
  • Transient Receptor Potential Channels / metabolism*

Substances

  • Membrane Proteins
  • TRPA1 Cation Channel
  • TRPV Cation Channels
  • TRPV1 protein, mouse
  • Tmem100 protein, mouse
  • Transient Receptor Potential Channels
  • Trpa1 protein, mouse