Iron-catalyzed asymmetric hydrosilylation of 1,1-disubstituted alkenes

Jianhui Chen; Biao Cheng; Minyi Cao; Zhan Lu

doi:10.1002/anie.201411884

Iron-catalyzed asymmetric hydrosilylation of 1,1-disubstituted alkenes

Angew Chem Int Ed Engl. 2015 Apr 7;54(15):4661-4. doi: 10.1002/anie.201411884. Epub 2015 Feb 18.

Authors

Jianhui Chen¹, Biao Cheng, Minyi Cao, Zhan Lu

Affiliation

¹ Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310028 (China) http://mypage.zju.edu.cn/lu.

PMID: 25693877
DOI: 10.1002/anie.201411884

Abstract

The highly regio- and enantioselective iron-catalyzed anti-Markovnikov hydrosilylation of 1,1-disubstituted aryl alkenes was developed using iminopyridine oxazoline ligands to afford chiral organosilanes. Additional derivatization of these products lead to chiral organosilanols, cyclic silanes, phenol derivatives, and 3-substituted 2,3-dihydrobenzofurans.

Keywords: arenes; asymmetric catalysis; iron; silicon; synthetic methods.