Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Yi-Hsiang Cheng; Tzu-Lung Lin; Yi-Jiun Pan; Yu-Ping Wang; Yi-Tsung Lin; Jin-Town Wang

doi:10.1128/AAC.04763-14

Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan

Antimicrob Agents Chemother. 2015 May;59(5):2909-13. doi: 10.1128/AAC.04763-14. Epub 2015 Feb 17.

Authors

Yi-Hsiang Cheng¹, Tzu-Lung Lin¹, Yi-Jiun Pan¹, Yu-Ping Wang², Yi-Tsung Lin², Jin-Town Wang³

Affiliations

¹ Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan.
² Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
³ Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan wangjt@ntu.edu.tw.

Abstract

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colistin / pharmacology*
Drug Resistance, Bacterial / genetics
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / genetics
Microbial Sensitivity Tests
Molecular Sequence Data
Taiwan

Substances

Colistin

Associated data

GENBANK/LC016506
GENBANK/LC016508
GENBANK/LC016697
GENBANK/LC016704