Abstract
Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.
Keywords:
Antioxidant properties; Natural products; Total synthesis; Toxicity; Zebrafish.
Published by Elsevier Ltd.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Animals
-
Antioxidants / chemical synthesis*
-
Antioxidants / pharmacology
-
Antioxidants / toxicity
-
Cladosporium / chemistry
-
Cladosporium / metabolism
-
Embryo, Nonmammalian / drug effects
-
Embryonic Development / drug effects
-
Fatty Acids, Unsaturated / chemical synthesis*
-
Fatty Acids, Unsaturated / chemistry
-
Fatty Acids, Unsaturated / toxicity
-
Models, Animal
-
Pyrones / chemical synthesis*
-
Pyrones / chemistry
-
Pyrones / toxicity
-
Zebrafish / growth & development
Substances
-
Antioxidants
-
Fatty Acids, Unsaturated
-
Pyrones
-
herbarin A