Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1192-5. doi: 10.1016/j.bmcl.2015.01.065. Epub 2015 Feb 4.

Abstract

Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.

Keywords: Antioxidant properties; Natural products; Total synthesis; Toxicity; Zebrafish.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antioxidants / chemical synthesis*
  • Antioxidants / pharmacology
  • Antioxidants / toxicity
  • Cladosporium / chemistry
  • Cladosporium / metabolism
  • Embryo, Nonmammalian / drug effects
  • Embryonic Development / drug effects
  • Fatty Acids, Unsaturated / chemical synthesis*
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / toxicity
  • Models, Animal
  • Pyrones / chemical synthesis*
  • Pyrones / chemistry
  • Pyrones / toxicity
  • Zebrafish / growth & development

Substances

  • Antioxidants
  • Fatty Acids, Unsaturated
  • Pyrones
  • herbarin A