Structure and biosynthetic implication of 5R-(N-acetyl-L-cysteinyl)-14S-hydroxy-dihydrokalafungin from a mutant of the actVA-ORF4 gene for actinorhodin biosynthesis in Streptomyces coelicolor A3(2)

J Antibiot (Tokyo). 2015 Jul;68(7):481-3. doi: 10.1038/ja.2015.13. Epub 2015 Feb 18.

Authors

Takaaki Taguchi¹, Tomoki Maruyama¹, Ryuichi Sawa², Masayuki Igarashi², Susumu Okamoto³, Koji Ichinose¹

Affiliations

¹ Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan.
² Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan.
³ National Food Research Institute, Tsukuba, Japan.

PMID: 25690356
DOI: 10.1038/ja.2015.13

No abstract available

MeSH terms

Anthraquinones / metabolism
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Biosynthetic Pathways / genetics*
Molecular Structure
Mutant Proteins / genetics
Mutant Proteins / metabolism
Naphthoquinones / chemistry
Naphthoquinones / isolation & purification*
Naphthoquinones / metabolism*
Spectrum Analysis
Streptomyces coelicolor / enzymology*
Streptomyces coelicolor / genetics
Streptomyces coelicolor / metabolism*

Substances

Anthraquinones
Bacterial Proteins
Mutant Proteins
Naphthoquinones
actinorhodin