Coronary artery disease in primary biliary cirrhosis: A systematic review and meta-analysis of observational studies

Patompong Ungprasert; Karn Wijarnpreecha; Wasin Ahuja; Ittikorn Spanuchart; Charat Thongprayoon

doi:10.1111/hepr.12452

Coronary artery disease in primary biliary cirrhosis: A systematic review and meta-analysis of observational studies

Hepatol Res. 2015 Nov;45(11):1055-61. doi: 10.1111/hepr.12452. Epub 2014 Dec 15.

Authors

Patompong Ungprasert^{1

2}, Karn Wijarnpreecha³, Wasin Ahuja⁴, Ittikorn Spanuchart⁵, Charat Thongprayoon⁶

Affiliations

¹ Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
² Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³ Cardiac Electrophysiology Unit, Department of Physiology, Chiang Mai University, Chiang Mai, Thailand.
⁴ Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
⁵ Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
⁶ Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

PMID: 25689394
DOI: 10.1111/hepr.12452

Abstract

Aim: To investigate the association between primary biliary cirrhosis (PBC) and risk of coronary artery disease (CAD).

Methods: We conducted a systematic review and meta-analysis of published observational studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratios with 95% confidence intervals (CI) comparing CAD risk in patients with PBC versus non-PBC controls. Pooled risk ratios and 95% confidence intervals were combined using a random-effect model and generic inverse variance of DerSimonian and Laird methods.

Result: Four studies with 3362 patients with PBC were identified and included in our data analysis. The pooled risk ratio of CAD in patients with PBC was 1.57 (95% CI, 1.21-2.06). The statistical heterogeneity was low with an I(2) of 38%.

Conclusion: Our study demonstrated a statistically significant increased risk of CAD among patients with PBC.

Keywords: coronary artery disease; epidemiology; meta-analysis; primary biliary cirrhosis.