Total syntheses and biological evaluation of miuraenamides

Abstract

The miuraenamides, relatively simple representatives of a class of cyclodepsipeptides with high antitumor activity, can be easily and flexibly obtained by the concept of peptide modification. A reaction sequence consisting of an aldol reaction, oxidation, and methylation of the glycine subunit of the cyclodepsipeptides allows the incorporation of the unusual α,β-unsaturated dehydroamino acid in one of the last steps of the synthesis.

Keywords: actin-binding compounds; antitumor activity; cyclodepsipeptides; miuraenamides; natural products.