Specific genetic features of Campylobacter jejuni strain G1 revealed by genome sequencing

Abstract

This report describes a draft genome sequence of Campylobacter jejuni strain G1. The strain contains no plasmids, despite being resistant to tetracycline (Tet). Comparison of the genome of this strain with that of a reference strain NCTC 11168 (Tet sensitive) revealed the presence of a candidate gene that may be responsible for antibiotic resistance, as well as the genes involved in the synthesis of ganglioside-mimicking molecules responsible for the development of a neurodegenerative disorder, Guillain-Barré syndrome.

Keywords: Guillaine–Barré syndrome; ganglioside mimicry; lipo-oligosaccharide; multidrug efflux pump; tetracycline resistance.