Clinical outcomes for teeth treated with electrospun poly(ε-caprolactone) fiber meshes/mineral trioxide aggregate direct pulp capping

Li-Wan Lee; Sheng-Huang Hsiao; Wei-Chiang Hung; Yun-Ho Lin; Po-Yu Chen; Chun-Pin Chiang

doi:10.1016/j.joen.2015.01.007

Clinical outcomes for teeth treated with electrospun poly(ε-caprolactone) fiber meshes/mineral trioxide aggregate direct pulp capping

J Endod. 2015 May;41(5):628-36. doi: 10.1016/j.joen.2015.01.007. Epub 2015 Feb 14.

Authors

Li-Wan Lee¹, Sheng-Huang Hsiao², Wei-Chiang Hung³, Yun-Ho Lin⁴, Po-Yu Chen⁵, Chun-Pin Chiang⁶

Affiliations

¹ Department of Dentistry, Taipei City Hospital, Renai Branch, Taipei, Taiwan.
² Department of Neurosurgery, Taipei City Hospital, Renai Branch, Taipei, Taiwan; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
³ School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Division of Endodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan.
⁴ School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Division of Oral Pathology, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan.
⁵ Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan.
⁶ Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan. Electronic address: cpchiang@ntu.edu.tw.

PMID: 25687364
DOI: 10.1016/j.joen.2015.01.007

Abstract

Introduction: Mineral trioxide aggregate (MTA) is a biocompatible material for direct pulp capping. This study was designed to compare the clinical outcomes of pulp-exposed teeth treated with either poly(ε-caprolactone) fiber mesh (PCL-FM) as a barrier for MTA (so-called PCL-FM/MTA) or MTA direct pulp capping.

Methods: Sixty human vital teeth were evenly divided into 4 groups (n = 15 in each group). Teeth in groups 1 and 3 had pulp exposure <1 mm in diameter, whereas teeth in groups 2 and 4 had pulp exposure of 1-1.5 mm in diameter. Teeth in groups 1 and 2 were treated with PCL-FM/MTA direct pulp capping, and those in groups 3 and 4 were treated with MTA direct pulp capping.

Results: Teeth treated with PCL-FM/MTA direct pulp capping needed a significantly shorter mean duration for dentin bridge formation than teeth treated with MTA direct pulp capping. Moreover, teeth with pulp exposure <1.0 mm in diameter needed a significantly shorter mean duration for dentin bridge formation than teeth with pulp exposure of 1-1.5 mm in diameter after either PCL-FM/MTA or MTA direct pulp capping treatment. In addition, teeth treated with PCL-FM/MTA direct pulp capping formed an approximately 3-fold thicker dentin bridge than teeth treated with MTA direct pulp capping 8 weeks or 3 months later. Furthermore, none of the teeth treated with PCL-FM/MTA direct pulp capping showed tooth discoloration after treatment for 3 months.

Conclusions: PCL-FM/MTA is a better combination material than MTA alone for direct pulp capping of human permanent teeth.

Keywords: Clinical outcome; dentin bridge; direct pulp capping; mineral trioxide aggregate; poly(ε-caprolactone) fiber meshes; pulp-exposed permanent teeth.

MeSH terms

Adolescent
Adult
Aged
Aluminum Compounds*
Biocompatible Materials
Calcium Compounds*
Child
Dental Pulp Capping / methods*
Drug Combinations
Female
Humans
Male
Materials Testing
Middle Aged
Oxides*
Polyesters*
Pulp Capping and Pulpectomy Agents*
Silicates*
Treatment Outcome
Young Adult

Substances

Aluminum Compounds
Biocompatible Materials
Calcium Compounds
Drug Combinations
Oxides
Polyesters
Pulp Capping and Pulpectomy Agents
Silicates
mineral trioxide aggregate
polycaprolactone