Complete genome sequence of Streptomyces vietnamensis GIMV4.0001 T, a genetically manipulable producer of the benzoisochromanequinone antibiotic granaticin

J Biotechnol. 2015 Apr 20:200:6-7. doi: 10.1016/j.jbiotec.2015.02.009. Epub 2015 Feb 14.

Abstract

We report the complete genome sequence of Streptomyces vietnamensis GIMV4.0001(T), a new and genetically manipulable producer of the benzoisochromanequinone antibiotic granaticin, whose unique sugar attachment pattern in structure has drawn much attention among chemical and biochemical researchers. The genome of S. vietnamensis GIMV4.0001(T) consists of one linear chromosome (8,867,142 bp, 72.09% G+C content) and one linear megaplasmid named pSVL1 (286,635 bp, 69.04% G+C content), encoding a total of 7356 protein coding genes. Twenty-nine gene clusters for secondary metabolites were predicted on the chromosome.

Keywords: Genome sequence; Granaticin; Streptomyces.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Base Sequence
  • Chromosomes, Bacterial*
  • Genome, Bacterial*
  • Molecular Sequence Data
  • Naphthoquinones / metabolism
  • Streptomyces / genetics*
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • Naphthoquinones
  • granaticin

Associated data

  • GENBANK/CP010407
  • GENBANK/CP010408