New pregnane glycosides from Gymnema sylvestre

Molecules. 2015 Feb 12;20(2):3050-66. doi: 10.3390/molecules20023050.

Abstract

Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycoside Hydrolase Inhibitors* / chemistry
  • Glycoside Hydrolase Inhibitors* / isolation & purification
  • Glycosides* / chemistry
  • Glycosides* / isolation & purification
  • Gymnema sylvestre / chemistry*
  • Pregnanes* / chemistry
  • Pregnanes* / isolation & purification
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae Proteins* / antagonists & inhibitors
  • Saccharomyces cerevisiae Proteins* / chemistry
  • alpha-Glucosidases / chemistry*

Substances

  • Glycoside Hydrolase Inhibitors
  • Glycosides
  • Pregnanes
  • Saccharomyces cerevisiae Proteins
  • alpha-Glucosidases