Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Mohammad H Rahbar; Maureen Samms-Vaughan; Jianzhong Ma; Jan Bressler; Katherine A Loveland; Manouchehr Hessabi; Aisha S Dickerson; Megan L Grove; Sydonnie Shakespeare-Pellington; Compton Beecher; Wayne McLaughlin; Eric Boerwinkle

doi:10.1016/j.rasd.2014.12.008

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Res Autism Spectr Disord. 2015 Apr 1:12:1-9. doi: 10.1016/j.rasd.2014.12.008.

Affiliations

¹ Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, and Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, and Biostatistics/Epidemiology/Research Design (BERD) component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
² Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston, Jamaica.
³ Division of Clinical and Translational Sciences, Department of Internal Medicine, Medical School, and Biostatistics/Epidemiology/Research Design (BERD) component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
⁴ Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas 77030, USA.
⁵ Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston, Houston, Texas 77054, USA.
⁶ Biostatistics/Epidemiology/Research Design component, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
⁷ Department of Child & Adolescent Health, The University of West Indies, Mona Campus, Kingston, Jamaica.
⁸ Department of Basic Medical Sciences, The University of the West Indies, Mona Campus, Kingston, Jamaica.
⁹ Caribbean Genetics (CARIGEN), The University of the West Indies, Mona Campus, Kingston, Jamaica.
¹⁰ Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, and Human Genetics Center, University of Texas School of Public Health at Houston, Houston, Texas 77030, USA.

Abstract

We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2-8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [Matched Odds Ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted.

Keywords: Autism spectrum disorder; Modulating-factor; Oxidative stress; gene-gene interaction; glutathione S-transferase (GST) genes.

Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders

Authors

Affiliations

Abstract

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