Abstract
We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochemical and optical properties of the resulting MB modified oligonucleotides were confirmed. This new molecule is an important breakthrough in the design of new probes labelled with MB.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Electrochemical Techniques
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Methylene Blue / chemistry*
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Oligonucleotides / chemical synthesis
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Oligonucleotides / chemistry*
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Organophosphorus Compounds / chemistry*
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Solid-Phase Synthesis Techniques
Substances
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Oligonucleotides
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Organophosphorus Compounds
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phosphoramidite
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Methylene Blue