Abstract
The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.
MeSH terms
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Aminopyridines / pharmacology
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Autophagy / drug effects
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Autophagy / physiology*
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Cell Communication
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Class III Phosphatidylinositol 3-Kinases / antagonists & inhibitors
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Class III Phosphatidylinositol 3-Kinases / physiology*
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Humans
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Intracellular Signaling Peptides and Proteins
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Nuclear Receptor Coactivators / genetics
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Nuclear Receptor Coactivators / metabolism
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Proteins / genetics
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Pyridines / pharmacology
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Pyrimidines / pharmacology
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Pyrimidinones / pharmacology
Substances
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1-((2-((2-chloropyridin-4yl)amino)-4'-(cyclopropylmethyl)-(4,5'-bipyrimidin)-2'-yl)amino)-2-methylpropan-2-ol
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Aminopyridines
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Intracellular Signaling Peptides and Proteins
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NBR1 protein, human
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NCOA4 protein, human
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Nuclear Receptor Coactivators
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Proteins
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Pyridines
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Pyrimidines
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Pyrimidinones
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SAR405
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Class III Phosphatidylinositol 3-Kinases