Ironing out VPS34 inhibition

Nat Cell Biol. 2015 Jan;17(1):1-3. doi: 10.1038/ncb3089.

Abstract

The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.

MeSH terms

  • Aminopyridines / pharmacology
  • Autophagy / drug effects
  • Autophagy / physiology*
  • Cell Communication
  • Class III Phosphatidylinositol 3-Kinases / antagonists & inhibitors
  • Class III Phosphatidylinositol 3-Kinases / physiology*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Receptor Coactivators / genetics
  • Nuclear Receptor Coactivators / metabolism
  • Proteins / genetics
  • Pyridines / pharmacology
  • Pyrimidines / pharmacology
  • Pyrimidinones / pharmacology

Substances

  • 1-((2-((2-chloropyridin-4yl)amino)-4'-(cyclopropylmethyl)-(4,5'-bipyrimidin)-2'-yl)amino)-2-methylpropan-2-ol
  • Aminopyridines
  • Intracellular Signaling Peptides and Proteins
  • NBR1 protein, human
  • NCOA4 protein, human
  • Nuclear Receptor Coactivators
  • Proteins
  • Pyridines
  • Pyrimidines
  • Pyrimidinones
  • SAR405
  • Class III Phosphatidylinositol 3-Kinases