Drug discovery. Tying up a transcription factor

Science. 2015 Feb 13;347(6223):713-4. doi: 10.1126/science.aaa6119.

Authors

Andrew Chen¹, Angela N Koehler²

Affiliations

¹ Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
² Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Broad Institute of MIT and Harvard, Cambridge, MA, USA. koehler@mit.edu.

PMID: 25678644
DOI: 10.1126/science.aaa6119

No abstract available

Publication types

Comment

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
Benzimidazoles / therapeutic use*
Female
Humans
Leukemia, Myeloid, Acute / drug therapy*
Oncogene Proteins, Fusion / antagonists & inhibitors*

Substances

2,2'-(5,5'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(6-(trifluoromethoxy)-1H-benzo(d)imidazole)
Antineoplastic Agents
Benzimidazoles
CBFbeta-MYH11 fusion protein
Oncogene Proteins, Fusion