Regulatory small RNAs from the 3' regions of bacterial mRNAs

Masatoshi Miyakoshi; Yanjie Chao; Jörg Vogel

doi:10.1016/j.mib.2015.01.013

Regulatory small RNAs from the 3' regions of bacterial mRNAs

Curr Opin Microbiol. 2015 Apr:24:132-9. doi: 10.1016/j.mib.2015.01.013. Epub 2015 Feb 9.

Authors

Masatoshi Miyakoshi¹, Yanjie Chao¹, Jörg Vogel²

Affiliations

¹ RNA Biology Group, Institute for Molecular Infection Biology, University of Würzburg, Josef-Schneider-Straße 2, D-97080 Würzburg, Germany.
² RNA Biology Group, Institute for Molecular Infection Biology, University of Würzburg, Josef-Schneider-Straße 2, D-97080 Würzburg, Germany. Electronic address: joerg.vogel@uni-wuerzburg.de.

PMID: 25677420
DOI: 10.1016/j.mib.2015.01.013

Abstract

Most studies of small regulatory RNAs in bacteria have focussed on conserved transcripts in intergenic regions. However, several recent developments including single-nucleotide resolution transcriptome profiling by RNA-seq and increased knowledge of the cellular targets of the RNA chaperone Hfq suggest that the bacterial world of functional small RNAs is more diverse. One emerging class are small RNAs that are identical to the 3' regions of known mRNAs, but are produced either by transcription from internal promoters or by mRNA processing. Using several recently discovered examples of such sRNAs, we discuss their biogenesis and modes of action, and illustrate how they can facilitate mRNA crosstalk in various physiological processes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacteria / genetics*
Gene Expression Profiling
Gene Expression Regulation, Bacterial*
RNA 3' End Processing
RNA, Bacterial / genetics
RNA, Messenger / genetics*
RNA, Small Untranslated / genetics*

Substances

RNA, Bacterial
RNA, Messenger
RNA, Small Untranslated