Abstract
Experience of treatment of 176 patients, suffering thrombotic complications of severe forms of the lower extremities varicose disease (VDLE), was analyzed. In 20 patients, suffering varicothrombophlebitis (VTHPH) in severe forms of VDLE, morphological and immunohistochemical changes in the venous wall and surrounding tissues were studied. There were examined 28 patients, in whom thrombotic complications of the VDLE have had occurred, using diagnostic complex "PLR genetics thrombophilia". Recurrent course of thrombotic complications and coexistence of VTHPH and thrombosis of deep veins have had constitute the main criterion of such patients selection. The groups of patients, suffering severe forms of VDLE, were delineated, depending on thrombotic process localization, differentiated tactics of their surgical treatment was proposed.
MeSH terms
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Adult
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Aged
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Blood Coagulation Factors / genetics
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Blood Coagulation Factors / metabolism
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Endothelial Cells / ultrastructure
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Female
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Femoral Vein / pathology
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Femoral Vein / surgery
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Gene Expression
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Humans
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Immunohistochemistry
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Integrin alpha2 / blood
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Integrin alpha2 / genetics
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Integrin beta3 / blood
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Integrin beta3 / genetics
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Leg / blood supply
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Leg / pathology
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Leg / surgery*
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Male
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Middle Aged
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Myocytes, Smooth Muscle / metabolism
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Myocytes, Smooth Muscle / pathology
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Myocytes, Smooth Muscle / ultrastructure
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Plasminogen Activator Inhibitor 1 / genetics
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Plasminogen Activator Inhibitor 1 / metabolism
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Saphenous Vein / pathology
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Saphenous Vein / surgery
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Thrombophilia / blood
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Thrombophilia / pathology
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Thrombophilia / surgery*
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Varicose Veins / blood
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Varicose Veins / complications
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Varicose Veins / pathology
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Varicose Veins / surgery*
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Venous Thrombosis / blood
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Venous Thrombosis / etiology
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Venous Thrombosis / pathology
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Venous Thrombosis / surgery*
Substances
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Blood Coagulation Factors
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ITGB3 protein, human
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Integrin alpha2
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Integrin beta3
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Plasminogen Activator Inhibitor 1
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SERPINE1 protein, human
Supplementary concepts
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Thrombophilia, hereditary