Abstract
Six Diels-Alder adducts (1-6) and nine prenylated flavanones (7-15) were isolated from the root bark of Morus alba L. Among them, soroceal B (1) and sanggenol Q (7) were new compounds. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques. Compounds 1-3, 9, 10, 12, 13 and 15 exhibited cytotoxic activity against five human tumour lines and compound 2 inhibited significantly selective cytotoxic activities towards HL-60 and AGS cells with IC50 of 3.4 and 3.6 μM. Compounds 3, 5, 9 and 12 exhibited moderate inhibitory activity against nitric oxide production in LPS-activated RAW264.7.
Keywords:
Morus alba L; anti-inflammatory activity; cytotoxic activity; sanggenol Q; soroceal B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / isolation & purification
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Cell Line
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Cell Line, Tumor / drug effects
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Flavanones / chemistry
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Flavanones / isolation & purification
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HL-60 Cells / drug effects
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Humans
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Macrophages / drug effects
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Mice
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Molecular Structure
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Morus / chemistry*
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Nitric Oxide / biosynthesis
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Plant Roots / chemistry*
Substances
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Benzopyrans
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Flavanones
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Heterocyclic Compounds, 4 or More Rings
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sanggenol Q
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soroceal B
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Nitric Oxide