Abstract
Two new peptaibols, namely microbacterins A (1) and B (2), were isolated from the deep sea inhabited actinomycete Microbacterium sediminis spp. nov. YLB-01(T). The sequences of the amino acid residues were determined on the basis of intensive NMR and ESI-MS/MS spectroscopic analysis, in addition to the Marfey's method and CD and optical rotation data for the configurational assignment. Both 1 and 2 exhibited significant cytotoxic activities against a panel of human tumor cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actinobacteria / chemistry*
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Actinomycetales / chemistry*
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Amino Acids / chemistry*
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Amino Acids / pharmacology
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Cell Line, Tumor
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peptaibols / chemical synthesis
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Peptaibols / chemistry*
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Peptaibols / isolation & purification
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Peptaibols / pharmacology
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Tandem Mass Spectrometry
Substances
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Amino Acids
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Anti-Bacterial Agents
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Peptaibols
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microbacterin A
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microbacterin B