Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T)

Org Lett. 2015 Mar 6;17(5):1220-3. doi: 10.1021/acs.orglett.5b00172. Epub 2015 Feb 12.

Abstract

Two new peptaibols, namely microbacterins A (1) and B (2), were isolated from the deep sea inhabited actinomycete Microbacterium sediminis spp. nov. YLB-01(T). The sequences of the amino acid residues were determined on the basis of intensive NMR and ESI-MS/MS spectroscopic analysis, in addition to the Marfey's method and CD and optical rotation data for the configurational assignment. Both 1 and 2 exhibited significant cytotoxic activities against a panel of human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria / chemistry*
  • Actinomycetales / chemistry*
  • Amino Acids / chemistry*
  • Amino Acids / pharmacology
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Cell Line, Tumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Peptaibols / chemical synthesis
  • Peptaibols / chemistry*
  • Peptaibols / isolation & purification
  • Peptaibols / pharmacology
  • Tandem Mass Spectrometry

Substances

  • Amino Acids
  • Anti-Bacterial Agents
  • Peptaibols
  • microbacterin A
  • microbacterin B