Copper(II)-catalyzed electrophilic amination of quinoline N-oxides with O-benzoyl hydroxylamines

Org Biomol Chem. 2015 Mar 21;13(11):3207-10. doi: 10.1039/c5ob00135h.

Abstract

Copper acetate-catalyzed C-H bond functionalization amination of quinoline N-oxides was achieved using O-benzoyl hydroxylamine as an electrophilic amination reagent, thereby affording the desired products in moderate to excellent yields. Electrophilic amination can also be performed in good yield on a gram scale.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Catalysis
  • Copper / chemistry*
  • Hydroxylamine / chemistry*
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Oxides / chemistry*
  • Quinolines / chemistry*

Substances

  • Organometallic Compounds
  • Oxides
  • Quinolines
  • Hydroxylamine
  • Copper