Sugar and pH dual-responsive snap-top nanocarriers based on mesoporous silica-coated Fe3O4 magnetic nanoparticles for cargo delivery

Xi-Long Qiu; Qing-Lan Li; Yue Zhou; Xiao-Yu Jin; Ai-Di Qi; Ying-Wei Yang

doi:10.1039/c4cc10413g

Sugar and pH dual-responsive snap-top nanocarriers based on mesoporous silica-coated Fe3O4 magnetic nanoparticles for cargo delivery

Chem Commun (Camb). 2015 Mar 11;51(20):4237-40. doi: 10.1039/c4cc10413g.

Authors

Xi-Long Qiu¹, Qing-Lan Li, Yue Zhou, Xiao-Yu Jin, Ai-Di Qi, Ying-Wei Yang

Affiliation

¹ State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. ywyang@jlu.edu.cn.

PMID: 25670321
DOI: 10.1039/c4cc10413g

Abstract

A facile strategy to prepare snap-top magnetic nanocarriers has been developed where ultrasmall superparamagnetic Fe3O4 nanoparticles were used as the core with mesoporous silica as the shell followed by the covalent installation of a layer of β-cyclodextrins on the outer surfaces. The smart hybrid nanomaterials showed remarkable pH- and sugar-responsive cargo release property and low cytotoxicity as proved by an MTT assay with HEK293T cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Survival / drug effects
Dehydroascorbic Acid / chemistry*
Drug Carriers / chemistry*
Drug Carriers / pharmacology
Drug Liberation
Ferrosoferric Oxide / chemistry*
Ferrosoferric Oxide / pharmacology
HEK293 Cells
Humans
Hydrogen-Ion Concentration
Nanoparticles / chemistry*
Porosity
Silicon Dioxide / chemistry*
Silicon Dioxide / pharmacology
beta-Cyclodextrins / chemistry*
beta-Cyclodextrins / pharmacology

Substances

Drug Carriers
beta-Cyclodextrins
Silicon Dioxide
Ferrosoferric Oxide
Dehydroascorbic Acid