Abstract
The aim of the main research was investigated of interaction of neural, endocrine and immune systems under experimental postviral fatigue, behavioral reactions, level of corticosterone, changes of IL-3 and IL-10 gene expression in rats' hypothalamus and INF-α in hypothalamus and spleen were analyzed. It has been shown the decrease of physical activity, increasing of corticosterone's level and gene expression of cytokines after injection of Poly I:C as a model of postviral fatigue. After remedication of Poly I:C increasing of physical activity was shown.
MeSH terms
-
Animals
-
Corticosterone / blood
-
Disease Models, Animal
-
Fatigue Syndrome, Chronic / chemically induced
-
Fatigue Syndrome, Chronic / genetics
-
Fatigue Syndrome, Chronic / immunology
-
Fatigue Syndrome, Chronic / physiopathology*
-
Gene Expression
-
Hypothalamus / immunology
-
Hypothalamus / physiopathology*
-
Immunity, Innate
-
Interferon-alpha / genetics
-
Interferon-alpha / immunology
-
Interleukin-10 / genetics
-
Interleukin-10 / immunology
-
Interleukin-3 / genetics
-
Interleukin-3 / immunology
-
Male
-
Motor Activity / genetics
-
Motor Activity / immunology*
-
Poly I-C
-
Rats
-
Rats, Wistar
-
Spleen / immunology
-
Spleen / physiopathology*
-
Swimming
Substances
-
Interferon-alpha
-
Interleukin-3
-
Interleukin-10
-
Poly I-C
-
Corticosterone