Manganese-catalyzed synthesis of cis-β-amino acid esters through organometallic C-H activation of ketimines

Abstract

Manganese-catalyzed CH functionalization reactions of ketimines set the stage for the expedient synthesis of cis-β-amino acid esters through site- and regioselective alkene annulations. The organometallic CH activation occurred efficiently with high functional group tolerance, delivering densely functionalized β-amino acid derivatives with ample scope.

Keywords: CH activation; amino acids; manganese; reaction mechanisms; selectivity.