Surface charge regulation of osteogenic differentiation of mesenchymal stem cell on polarized ferroelectric crystal substrate

Jianhua Li; Xiaoning Mou; Jichuan Qiu; Shu Wang; Dongzhou Wang; Dehui Sun; Weibo Guo; Deshuai Li; Anil Kumar; Xuebin Yang; Aixue Li; Hong Liu

doi:10.1002/adhm.201500032

Surface charge regulation of osteogenic differentiation of mesenchymal stem cell on polarized ferroelectric crystal substrate

Adv Healthc Mater. 2015 May;4(7):998-1003. doi: 10.1002/adhm.201500032. Epub 2015 Feb 5.

Authors

Jianhua Li^{1

2}, Xiaoning Mou¹, Jichuan Qiu², Shu Wang¹, Dongzhou Wang², Dehui Sun², Weibo Guo¹, Deshuai Li¹, Anil Kumar¹, Xuebin Yang³, Aixue Li¹, Hong Liu^{1

2}

Affiliations

¹ Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
² State Key Lab of Crystal Materials, Shandong University, 27 Shandanan Road, Jinan, 250100, China.
³ Biomaterials and Tissue Engineering Group, School of Dentistry, University of Leeds, Leeds, LS2 9LU, UK.

PMID: 25663267
DOI: 10.1002/adhm.201500032

Abstract

Polarized ferroelectric crystal lithium niobate wafers with different cuts are selected to offer differently charged surfaces. By induction of the mesenchymal stem cells differentiation into osteoblasts on different charged surfaces, the specific osteogenic-associated markers are assessed and the results illustrate that the positively charged wafer surface enhances rBMMSCs osteogenic differentiation.

Keywords: mesenchymal stem cells; osteogenic differentiation; polarized ferroelectric crystals; surface charge.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation / drug effects
Cell Differentiation / physiology*
Cells, Cultured
Humans
Mesenchymal Stem Cells / drug effects
Mesenchymal Stem Cells / physiology*
Niobium / pharmacology
Osteoblasts / drug effects
Osteoblasts / physiology*
Osteogenesis / drug effects
Osteogenesis / physiology*
Oxides / pharmacology

Substances

Oxides
Niobium
lithium niobate