Tumor necrosis factor stimulates expression of CXCL12 in astrocytes

Immunobiology. 2015 Jul;220(7):845-50. doi: 10.1016/j.imbio.2015.01.007. Epub 2015 Jan 22.

Abstract

It has been increasingly appreciated that tumor necrosis factor (TNF) performs various protective and anti-inflammatory functions in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key inhibitor of leukocyte entry into the central nervous system (CNS) and as a regulator of inflammation resulting from the invasion. Here, a positive correlation between expression of TNF and CXCL12 in the CNS samples of EAE rats is presented. Also, it is shown that TNF potentiates CXCL12 expression in astrocytes. These results contribute to a view that TNF produced within the CNS plays a protective role in neuroinflammation.

Keywords: Astrocyte; CXCL12; Experimental autoimmune encephalomyelitis; Neuroinflammation; Tumor necrosis factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • Cell Movement
  • Cells, Cultured
  • Chemokine CXCL12 / biosynthesis*
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Inflammation / immunology
  • Inflammation Mediators / immunology
  • Leukocytes / metabolism
  • Multiple Sclerosis / immunology
  • Rats
  • Spinal Cord / metabolism
  • Tumor Necrosis Factor-alpha / metabolism*

Substances

  • CXCL12 protein, rat
  • Chemokine CXCL12
  • Inflammation Mediators
  • Tumor Necrosis Factor-alpha