Renal denervation for resistant hypertension
Rev Port Cardiol. 2015 Feb;34(2):125-35.
doi: 10.1016/j.repc.2014.07.011.
Epub 2015 Feb 7.
[Article in
English,
Portuguese]
Affiliations
- 1 Serviço de Cardiologia, Hospital de Santa Cruz - CHLO, Carnaxide, Portugal.
- 2 Serviço de Cardiologia, Hospital de Santa Cruz - CHLO, Carnaxide, Portugal; Departamento de Fisiopatologia, Faculdade de Ciências Médicas, UNL, Lisboa, Portugal. Electronic address: paraujogoncalves@yahoo.co.uk.
- 3 Serviço de Cardiologia, Hospital de Santa Maria, CHLN, Lisboa, Portugal; Instituto de Fisiologia, Faculdade de Medicina de Lisboa, UL, Lisboa, Portugal.
- 4 Serviço de Cardiologia, Hospital de Santo Antonio, CHP, Portugal; Unidade Curricular de Medicina I, Instituto de Ciências Biomédicas Abel Salazar, UP, Porto, Portugal.
Abstract
There is a marked contrast between the high prevalence of hypertension and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly involved. Sympathetic renal denervation has recently emerged as a device-based treatment for resistant hypertension. In this review, the pathophysiological mechanisms linking the sympathetic nervous system and cardiovascular disease are reviewed, focusing on resistant hypertension and the role of sympathetic renal denervation. An update on experimental and clinical results is provided, along with potential future indications for this device-based technique in other cardiovascular diseases.
Keywords:
Desnervação renal; Hipertensão arterial; Hypertension; Renal denervation; Sistema nervoso simpático; Sympathetic nervous system.
Copyright © 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.
MeSH terms
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Clinical Trials as Topic
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Coronary Vasospasm / complications
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Coronary Vasospasm / surgery*
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Forecasting
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Humans
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Hypertension / complications
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Hypertension / surgery*
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Kidney / innervation*
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Kidney / surgery*
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Sympathectomy
Supplementary concepts
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Hypertension Resistant to Conventional Therapy