The tenth annual Scottsdale Interventional Forum (SIF), which took place in Scottsdale, Arizona from March 5-8, 2014, brought together some of the leading experts in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) to review some of the current concepts and advances in this field. The topics discussed included review of the diagnostic coronary angiogram in the context of CTO-PCI; strategic approaches to CTO-PCI; the CTO toolbox; and review of antegrade and retrograde techniques.