Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

Dimitry A Chistiakov; Yuri V Bobryshev; Alexander N Orekhov

doi:10.1016/j.molimm.2015.01.013

Heterogeneity of Tregs and the complexity in the IL-12 cytokine family signaling in driving T-cell immune responses in atherosclerotic vessels

Mol Immunol. 2015 May;65(1):133-8. doi: 10.1016/j.molimm.2015.01.013. Epub 2015 Feb 3.

Authors

Dimitry A Chistiakov¹, Yuri V Bobryshev², Alexander N Orekhov³

Affiliations

¹ Research Center for Children's Health, 119991 Moscow, Russia; The Mount Sinai Community Clinical Oncology Program, Mount Sinai Comprehensive Cancer Center, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
² Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Kensington, Sydney, NSW 2052, Australia; School of Medicine, University of Western Sydney, Campbelltown, NSW 2560, Australia. Electronic address: y.bobryshev@unsw.edu.au.
³ Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow 125315, Russia; Institute for Atherosclerosis, Skolkovo Innovative Center, Moscow 143025, Russia.

PMID: 25659084
DOI: 10.1016/j.molimm.2015.01.013

Abstract

The importance of immune inflammation in the development and progression of atherosclerotic lesions is well recognized. Accumulated evidence shows striking features of heterogeneity of regulatory T cells (Tregs) and the importance of the IL-12 cytokine family in regulation of Tregs in atherogenesis. The present review briefly summarized the current knowledge about the impact of the IL-12 cytokine family in regulation of immune processes in atherogenesis.

Keywords: Arteries; Atherosclerosis; Immune reactions; Inflammation; Interleukin 12.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Atherosclerosis / immunology*
Atherosclerosis / pathology*
Dendritic Cells / immunology
Humans
Inflammation / immunology
Interleukin-12 / immunology*
Plaque, Atherosclerotic / pathology*
T-Lymphocytes, Regulatory / immunology*
Th1 Cells / immunology
Th17 Cells / immunology

Substances

Interleukin-12