The Interpersonal Exchange Model of Sexual Satisfaction Questionnaire (IEMSSQ) contains a number of separate measures that, together, have been useful in enhancing understanding of sexual satisfaction because it is based on a validated theoretical framework and has good psychometric properties. The present study aimed to determine the psychometric properties of the IEMSSQ in a Spanish sample of 520 men and 701 women in a mixed-sex relationship. Participants completed Spanish translations of the IEMSSQ, the Index of Sexual Satisfaction, the Dyadic Adjustment Scale, and the Massachusetts General Hospital-Sexual Functioning Questionnaire. The results showed that the Spanish IEMSSQ has good psychometric properties. Internal consistency values were excellent. For the most part, test-retest reliabilities were good, except for the equality components, for which they were moderate. Consistent with predictions, the various subscales were correlated with scores on sexual satisfaction, dyadic adjustment, and sexual functioning, demonstrating good concurrent and convergent validity. The applicability of the IEMSSQ for use with Spanish speakers in clinical and research settings is discussed.