IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals

K Machmach; C Abad-Molina; M C Romero-Sánchez; B Dominguez-Molina; M Moyano; M M Rodriguez; M Rafii-El-Idrissi Benhnia; M E Jimenez-Mejias; F Vidal; M A Muñoz-Fernández; M Genebat; P Viciana; M F González-Escribano; M Leal; E Ruiz-Mateos

doi:10.1016/j.cmi.2014.10.012

IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals

Clin Microbiol Infect. 2015 Mar;21(3):289.e1-4. doi: 10.1016/j.cmi.2014.10.012. Epub 2014 Oct 29.

Authors

Affiliations

¹ Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain.
² Immunology Service, Virgen del Rocío University Hospital, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
³ Centro Regional de Transfusiones Sanguíneas Sevilla/Huelva y Banco de Tejidos, Seville, Spain.
⁴ Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Department of Biochemistry and Molecular Biology & Immunology, Medical School, University of Seville, Seville, Spain.
⁵ Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain.
⁶ Hospital Universitari Joan XXIII, IISPV, Universitat Rovira I Virgili, Tarragona, Spain.
⁷ Laboratory of Molecular Immuno-Biology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.
⁸ Laboratory of Immunovirology, Biomedicine Institute of Seville, Virgen del Rocío University Hospital, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, IBIS/CSIC/SAS/University of Seville, Seville, Spain; Biochemistry Department, Virgen del Rocío University Hospital, Seville, Spain. Electronic address: ezequiel.ruizmateos@gmail.com.

PMID: 25658540
DOI: 10.1016/j.cmi.2014.10.012

Abstract

The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections.

Keywords: AIDS; CD4; HIV infection; IFNL4; IL28B.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles*
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Coinfection
Cross-Sectional Studies
Female
Genetic Linkage
Genotype
HIV Infections / drug therapy
HIV Infections / genetics*
HIV Infections / immunology*
Humans
Immunity / genetics*
Interleukins / genetics*
Linkage Disequilibrium
Male
Patient Outcome Assessment
Polymorphism, Genetic*
Polymorphism, Single Nucleotide
Prognosis
Spain
Viral Load

Substances

IFNL4 protein, human
Interleukins