Abstract
Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well-known natural and nature-inspired inhibitors of this second druggable Hsp90 site.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Binding Sites
-
Cell Cycle / drug effects
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Cell Survival / drug effects
-
Cells, Cultured
-
HSP90 Heat-Shock Proteins / antagonists & inhibitors*
-
HSP90 Heat-Shock Proteins / chemistry
-
HSP90 Heat-Shock Proteins / metabolism
-
Humans
-
Leukocytes, Mononuclear / drug effects
-
Ligands
-
Protein Structure, Tertiary
-
Pyrimidinones / chemistry
-
Pyrimidinones / pharmacology*
Substances
-
Antineoplastic Agents
-
HSP90 Heat-Shock Proteins
-
Ligands
-
Pyrimidinones