Abstract
An efficient protocol was developed to access 3-fluoro-2-hydroxy-2-substituted benzo[b]furans with Selectfluor™ as the fluorinating reagent in MeCN and water. By utilizing SOCl2/Py as the dehydrating agent, the compounds above were readily converted to 3-fluorinated, 2-substituted benzo[b]furans in high yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzofurans / chemistry*
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Diazonium Compounds / chemistry*
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Hydrocarbons, Fluorinated / chemical synthesis*
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Hydrocarbons, Fluorinated / chemistry
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Molecular Structure
Substances
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Benzofurans
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Diazonium Compounds
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Hydrocarbons, Fluorinated
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selectfluor
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benzofuran