Influence of the chirality of short peptide supramolecular hydrogels in protein crystallogenesis

Chem Commun (Camb). 2015 Mar 4;51(18):3862-5. doi: 10.1039/c4cc09024a.

Abstract

For the first time the influence of the chirality of the gel fibers in protein crystallogenesis has been studied. Enantiomeric hydrogels 1 and 2 were tested with model proteins lysozyme and glucose isomerase and a formamidase extracted from B. cereus. Crystallization behaviour and crystal quality of these proteins in both hydrogels are presented and compared.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldose-Ketose Isomerases / chemistry*
  • Amidohydrolases / chemistry*
  • Circular Dichroism
  • Crystallization
  • Hydrogels / chemistry*
  • Microscopy, Electron, Transmission
  • Muramidase / chemistry*
  • Peptides / chemistry*

Substances

  • Hydrogels
  • Peptides
  • Muramidase
  • Amidohydrolases
  • formamidase
  • Aldose-Ketose Isomerases
  • xylose isomerase