Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans

Fitoterapia. 2015 Apr:102:203-7. doi: 10.1016/j.fitote.2015.01.014. Epub 2015 Feb 2.

Abstract

Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute configurations were assigned by CD calculations. The acetylcholinesterase (AchE) inhibitory activity of compounds 1 and 2 was evaluated, both of which showed moderate activity with IC50 values of 11.8 and 13.5μM, respectively.

Keywords: AchE inhibitory activity; Dimeric indole derivatives; Marine actinomycetes; Rubrobacter radiotolerans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Actinomyces / chemistry*
  • Animals
  • Cell Line, Tumor
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / isolation & purification
  • Humans
  • Indoles / chemistry*
  • Indoles / isolation & purification
  • Inhibitory Concentration 50
  • Molecular Structure
  • Porifera / microbiology

Substances

  • Cholinesterase Inhibitors
  • Indoles
  • Acetylcholinesterase