A synthetic lethal approach targeting mutant isocitrate dehydrogenase in acute myeloid leukemia

Nat Med. 2015 Feb;21(2):113-4. doi: 10.1038/nm.3796.
No abstract available

Publication types

  • Comment

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Drug Resistance, Neoplasm / genetics*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Leukemia, Myeloid, Acute / genetics*
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
  • Sulfonamides / pharmacology*

Substances

  • Antineoplastic Agents
  • Bridged Bicyclo Compounds, Heterocyclic
  • Proto-Oncogene Proteins c-bcl-2
  • Sulfonamides
  • IDH2 protein, human
  • Isocitrate Dehydrogenase
  • IDH1 protein, human
  • venetoclax