Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa

Wu-Fu Chen; Chen-Ting Yin; Ching-Hsiao Cheng; Mei-Chin Lu; Lee-Shing Fang; Wei-Hsien Wang; Zhi-Hong Wen; Jih-Jung Chen; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/ijms16023298

Norcembranoidal diterpenes from the cultured-type octocoral Sinularia numerosa

Int J Mol Sci. 2015 Feb 3;16(2):3298-306. doi: 10.3390/ijms16023298.

Authors

Wu-Fu Chen¹, Chen-Ting Yin^{2

3}, Ching-Hsiao Cheng⁴, Mei-Chin Lu^{5

6}, Lee-Shing Fang⁷, Wei-Hsien Wang⁸, Zhi-Hong Wen⁹, Jih-Jung Chen¹⁰, Yang-Chang Wu^{11

12

13

14}, Ping-Jyun Sung^{15

16

17

18

19}

Affiliations

¹ Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. ma4949@cgmh.org.tw.
² Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. bear790516@gmail.com.
³ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. bear790516@gmail.com.
⁴ Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. ma4200@cgmh.org.tw.
⁵ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
⁶ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
⁷ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
⁸ Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. whw@mail.nsysu.edu.tw.
⁹ Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. wzh@mail.nsysu.edu.tw.
¹⁰ Department of Pharmacy, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
¹¹ School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹² Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹³ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁴ Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁵ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁶ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁷ Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.
¹⁸ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
¹⁹ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.

Abstract

A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cell Line, Tumor
Cell Survival / drug effects
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Diterpenes