Ligands specific to peripheral benzodiazepine receptors for treatment of porphyrias

Lancet. 1989 Apr 29;1(8644):932-3. doi: 10.1016/s0140-6736(89)92510-5.

Abstract

Accumulating data indicate that porphyrins are physiologically endogenous ligands to mitochondrial peripheral benzodiazepine receptors. An isoquinoline carboxamide derivative that likewise binds to peripheral benzodiazepine receptors could prove therapeutically useful in porphyrias by displacing porphyrins from these receptors in mitochondria.

MeSH terms

  • Humans
  • Isoquinolines / metabolism
  • Isoquinolines / therapeutic use*
  • Ligands
  • Mitochondria / metabolism*
  • Organ Specificity
  • Porphyrias / drug therapy*
  • Porphyrias / metabolism
  • Porphyrins / antagonists & inhibitors*
  • Porphyrins / metabolism
  • Receptors, GABA-A / metabolism*
  • Skin Diseases / drug therapy*
  • Skin Diseases / metabolism

Substances

  • Isoquinolines
  • Ligands
  • Porphyrins
  • Receptors, GABA-A
  • PK 11195