Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection

Tomoyasu Nishimura; Yukiko Fujita-Suzuki; Makoto Yonemaru; Kiyofumi Ohkusu; Takuro Sakagami; Stephen M Carpenter; Yoshihito Otsuka; Ho Namkoong; Ikuya Yano; Naoki Hasegawa

doi:10.1128/JCM.03339-14

Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection

J Clin Microbiol. 2015 Apr;53(4):1436-8. doi: 10.1128/JCM.03339-14. Epub 2015 Feb 4.

Authors

Affiliations

¹ Health Center, Keio University, Shinjuku, Tokyo, Japan.
² Japan BCG Central Laboratory, Kiyose, Tokyo, Japan.
³ Isehara Kyodo Hospital, Isehara, Kanagawa, Japan.
⁴ Department of Microbiology, Tokyo Medical University, Shinjuku, Tokyo, Japan.
⁵ Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan.
⁶ Department of Microbiology and Physiologic Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
⁷ Kameda Medical Center, Kamogawa, Chiba, Japan.
⁸ Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
⁹ Center of Infectious Diseases and Infection Control, Keio University School of Medicine, Shinjuku, Tokyo, Japan n-hasegawa@z8.keio.jp.

Abstract

We report a case of recurrent disseminated Mycobacterium avium complex (DMAC) disease with anti-gamma interferon autoantibodies. To our knowledge, this is the first reported case caused by reinfection with a separate isolate of M. avium. DMAC disease activity was monitored using serum IgG antibody titers against lipid antigens extracted from a MAC strain.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Autoantibodies / immunology*
Female
Humans
Interferon-gamma / immunology*
Mycobacterium avium Complex*
Mycobacterium avium-intracellulare Infection / immunology*
Mycobacterium avium-intracellulare Infection / microbiology*

Substances

Autoantibodies
Interferon-gamma