Abstract
Five new xanthones, garciniacowones A-E (1-5), together with 14 known xanthones, 6-19, were isolated from the young fruits and fresh flowers of Garcinia cowa. The structures of 1-5 were elucidated by analysis of their 1D and 2D NMR spectra and mass spectrometric data. The compounds 1-19 were tested in vitro for their antimicrobial activity and for their ability to inhibit α-glucosidase. Compounds 16 and 17 showed the most potent α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 and 8.7 ± 0.3 μM, respectively. Compounds 8, 9, and 19 showed antibacterial activity against Bacillus subtilis TISTR 088 with identical MIC values of 2 μg/mL, while 8, 10, and 19 exhibited antibacterial activity against Bacillus cereus TISTR 688 with identical MIC values of 4 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Bacillus cereus / drug effects
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Bacillus subtilis / drug effects
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Escherichia coli / drug effects
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Flowers / chemistry
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Fruit / chemistry
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Garcinia / chemistry*
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Glycoside Hydrolase Inhibitors / chemistry
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Glycoside Hydrolase Inhibitors / isolation & purification*
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Glycoside Hydrolase Inhibitors / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Prenylation
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Pseudomonas aeruginosa / drug effects
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Salmonella typhimurium / drug effects
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Staphylococcus aureus / drug effects
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Thailand
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Xanthones / chemistry
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Xanthones / isolation & purification*
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Xanthones / pharmacology*
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alpha-Glucosidases / drug effects*
Substances
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Anti-Bacterial Agents
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Glycoside Hydrolase Inhibitors
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Xanthones
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alpha-Glucosidases