A new way to silicone-based peptide polymers

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3778-82. doi: 10.1002/anie.201411065. Epub 2015 Feb 4.

Abstract

We describe a new class of silicone-containing peptide polymers obtained by a straightforward polymerization in water using tailored chlorodimethylsilyl peptide blocks as monomeric units. This general strategy is applicable to any type of peptide sequences, yielding linear or branched polymer chains composed of well-defined peptide sequences.

Keywords: biopolymers; comb polymers; dimers; hybrid peptides; siloxane bonds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Biopolymers / chemistry*
  • Biopolymers / metabolism
  • Cholecystokinin / chemistry
  • Cholecystokinin / metabolism
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Binding
  • Silanes / chemical synthesis
  • Silanes / chemistry
  • Silicones / chemistry*
  • Water / chemistry

Substances

  • Biopolymers
  • Peptides
  • Silanes
  • Silicones
  • Water
  • Cholecystokinin