TGF-β may control the switch between tumorigenic growth and "stem cell/mesenchymal" potentially drug-resistant states

Dermatol Ther. 2015 May-Jun;28(3):177-8. doi: 10.1111/dth.12199. Epub 2015 Feb 3.
No abstract available

Keywords: TGF-beta; differentiation; drug-resistance; epithelial-mesenchymal transition; melanoma; tumor stem cells.

MeSH terms

  • Animals
  • Cell Proliferation* / drug effects
  • Drug Resistance, Neoplasm
  • Humans
  • Melanocytes / drug effects
  • Melanocytes / metabolism*
  • Melanocytes / pathology
  • Melanoma / drug therapy
  • Melanoma / metabolism*
  • Melanoma / pathology
  • Mesenchymal Stem Cells / drug effects
  • Mesenchymal Stem Cells / metabolism*
  • Mesenchymal Stem Cells / pathology
  • Mice
  • Neoplastic Stem Cells / drug effects
  • Neoplastic Stem Cells / metabolism*
  • Neoplastic Stem Cells / pathology
  • Signal Transduction
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / metabolism*
  • Skin Neoplasms / pathology
  • Transforming Growth Factor beta / metabolism*

Substances

  • Transforming Growth Factor beta