Abstract
A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-14, was identified in clinical isolate Acinetobacter lwoffii JN49-1, which was recovered from an intensive care unit patient at a local hospital in China. NDM-14, which differs from other existing enzymes by an amino acid substitution at position 130 (Asp130Gly), possesses enzymatic activity toward carbapenems that is greater than that of NDM-1. Kinetic data indicate that NDM-14 has a higher affinity for imipenem and meropenem.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter / drug effects*
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Acinetobacter Infections / microbiology
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Amino Acid Substitution
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Anti-Bacterial Agents / pharmacology
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Carbapenems / metabolism
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China
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Cross Infection / microbiology
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Drug Resistance, Bacterial / genetics
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Humans
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Imipenem / metabolism
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Intensive Care Units
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Kinetics
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Meropenem
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Molecular Sequence Data
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Plasmids / genetics
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Thienamycins / metabolism
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Carbapenems
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Thienamycins
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Imipenem
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beta-Lactamases
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beta-lactamase NDM-1
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Meropenem