A novel New Delhi metallo-β-lactamase variant, NDM-14, isolated in a Chinese Hospital possesses increased enzymatic activity against carbapenems

Antimicrob Agents Chemother. 2015 Apr;59(4):2450-3. doi: 10.1128/AAC.05168-14. Epub 2015 Feb 2.

Abstract

A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-14, was identified in clinical isolate Acinetobacter lwoffii JN49-1, which was recovered from an intensive care unit patient at a local hospital in China. NDM-14, which differs from other existing enzymes by an amino acid substitution at position 130 (Asp130Gly), possesses enzymatic activity toward carbapenems that is greater than that of NDM-1. Kinetic data indicate that NDM-14 has a higher affinity for imipenem and meropenem.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter Infections / microbiology
  • Amino Acid Substitution
  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / metabolism
  • China
  • Cross Infection / microbiology
  • Drug Resistance, Bacterial / genetics
  • Humans
  • Imipenem / metabolism
  • Intensive Care Units
  • Kinetics
  • Meropenem
  • Molecular Sequence Data
  • Plasmids / genetics
  • Thienamycins / metabolism
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Thienamycins
  • Imipenem
  • beta-Lactamases
  • beta-lactamase NDM-1
  • Meropenem