Trap Effect of Three-Dimensional Fibers Network for High Efficient Cancer-Cell Capture

Lan Ma; Gao Yang; Nü Wang; Pengchao Zhang; Fengyun Guo; Jingxin Meng; Feilong Zhang; Zuojun Hu; Shutao Wang; Yong Zhao

doi:10.1002/adhm.201400650

Trap Effect of Three-Dimensional Fibers Network for High Efficient Cancer-Cell Capture

Adv Healthc Mater. 2015 Apr 22;4(6):838-43. doi: 10.1002/adhm.201400650. Epub 2015 Jan 21.

Authors

Lan Ma¹, Gao Yang, Nü Wang, Pengchao Zhang, Fengyun Guo, Jingxin Meng, Feilong Zhang, Zuojun Hu, Shutao Wang, Yong Zhao

Affiliation

¹ Key Laboratory of Bio-Inspired Smart Interfacial, Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China.

PMID: 25645204
DOI: 10.1002/adhm.201400650

Abstract

Cells are trapped: The 3D fibrous interfaces, including microfibers, nanofibers, and nanofibers/microbeads composite interfaces, are fabricated by electrospinning. After coated with anti-EpCAM, these 3D fibrous interfaces allow cancer cells to be firmly trapped into the networks that show the outstanding capability for cancer cell capture from real blood.

Keywords: 3D fibrous interfaces; cancer cell capture; electrospinning; trap effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Humans
MCF-7 Cells
Neoplasms / pathology*
Tissue Scaffolds*