Permanent transoral surgery of bilateral vocal fold paralysis: a prospective multi-center trial

Tadeus Nawka; Christian Sittel; Markus Gugatschka; Christoph Arens; Ruth Lang-Roth; Claus Wittekindt; Rudolf Hagen; Andreas H Müller; Gerd F Volk; Orlando Guntinas-Lichius

doi:10.1002/lary.25137

Permanent transoral surgery of bilateral vocal fold paralysis: a prospective multi-center trial

Laryngoscope. 2015 Jun;125(6):1401-8. doi: 10.1002/lary.25137. Epub 2015 Jan 30.

Authors

Affiliations

¹ Department of Audiology and Phoniatrics, Charité University Medicine Berlin, Berlin, Germany.
² Department of Otorhinolaryngology, Klinikum Stuttgart, Katharinenhospital, Stuttgart, Germany.
³ Department of Otorhinolaryngology, Medical University of Graz, Graz, Austria.
⁴ Department of Otorhinolaryngology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Giessen and Marburg, Giessen, Germany.
⁷ Department of Otorhinolaryngology, University of Wuerzburg, Wuerzburg, Germany.
⁸ Department of Otorhinolaryngology, SRH Wald-Klinikum Gera, Gera, Germany.
⁹ Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

PMID: 25643933
DOI: 10.1002/lary.25137

Abstract

Objectives/hypothesis: To describe postoperative adverse events (AEs) and outcomes after transoral surgery for bilateral vocal fold paralysis (BVFP).

Study design: Prospective observational multicenter study.

Methods: Thirty-six patients with BVFP underwent transoral surgery using standard surgical procedures to unilaterally widen the glottic area. Postoperative adverse events (AEs) including severe adverse events (SAEs) were registered continuously. Pre- and 6-month postoperative evaluations included the 6-Minute Walk Test, the 36-Item Short Form Health Survey (SF-36), the Glasgow Benefit Inventory, the 12-Item Voice Handicap Index (VHI-12), and a Fiberoptic Endoscopic Evaluation of Swallowing graded according to the Penetration-Aspiration-Scale.

Results: The patients underwent posterior cordotomy, partial arytenoidectomy, or permanent laterofixation as single procedures or in combination. Forty-seven percent of the patients had postoperative AEs. Dyspnea was the most frequent AE (45%). In 40% of AEs, the events were severe (SAEs), and 72.5% were related to the study intervention. Revision surgery leading to prolonged hospitalization or rehospitalization was necessary in nine cases (25%). Laterofixation was correlated to a decreased risk of AEs (P = 0.042). Six months after surgery, a significant improvement was seen in the SF-domains: Physical component score (P = 0.008), physical functioning (P = 0.001), physical role (P = 0.031), and vitality (P = 0.032). Concerning the voice handicap, only the VHI-12 physical subscore showed a decrease (P = 0.005). The total score and other VHI-12 subscores did not change significantly (all P > 0.05).

Conclusion: BCVP patients profit from modern transoral surgery for unilateral glottic widening; quality of life is improved; and the voice is preserved. Nevertheless, postoperative complications are frequent.

Level of evidence: 2b.

Keywords: Bilateral vocal fold paralysis; prospective study; transoral approach; treatment outcome.

Publication types

Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Female
Health Status Indicators
Humans
Male
Middle Aged
Otorhinolaryngologic Surgical Procedures / methods*
Prospective Studies
Quality of Life
Treatment Outcome
Vocal Cord Paralysis / surgery*
Young Adult