Abstract
One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP). The resulting EPI-RNA-CaP nanocomplexes can achieve a spatial-temporal synchronous effect to full-scale overcome sophisticated multiple drug resistance (MDR) by simultaneous inhibitions of drug efflux and intracellular anti-apoptotic defense to maximize the therapeutic efficacy.
Keywords:
RNA interference; epirubicin; gene therapy; multiple drug resistance; synergistic effect.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / chemistry
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Apoptosis / drug effects*
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Apoptosis / genetics*
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Calcium Phosphates / chemistry
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Drug Combinations
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Epirubicin / administration & dosage*
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Gene Silencing
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Hep G2 Cells
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Humans
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Nanocapsules / administration & dosage
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Nanocapsules / chemistry*
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Nanocapsules / ultrastructure
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Proto-Oncogene Proteins c-bcl-2 / genetics
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RNA, Small Interfering / administration & dosage*
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RNA, Small Interfering / genetics*
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Spatio-Temporal Analysis
Substances
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Antibiotics, Antineoplastic
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BCL2 protein, human
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Calcium Phosphates
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Drug Combinations
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Nanocapsules
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Proto-Oncogene Proteins c-bcl-2
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RNA, Small Interfering
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Epirubicin
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calcium phosphate