Overcoming multiple drug resistance by spatial-temporal synchronization of epirubicin and pooled siRNAs

Small. 2015 Apr 17;11(15):1775-81. doi: 10.1002/smll.201402377. Epub 2015 Jan 12.

Abstract

One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP). The resulting EPI-RNA-CaP nanocomplexes can achieve a spatial-temporal synchronous effect to full-scale overcome sophisticated multiple drug resistance (MDR) by simultaneous inhibitions of drug efflux and intracellular anti-apoptotic defense to maximize the therapeutic efficacy.

Keywords: RNA interference; epirubicin; gene therapy; multiple drug resistance; synergistic effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / chemistry
  • Apoptosis / drug effects*
  • Apoptosis / genetics*
  • Calcium Phosphates / chemistry
  • Drug Combinations
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Epirubicin / administration & dosage*
  • Gene Silencing
  • Hep G2 Cells
  • Humans
  • Nanocapsules / administration & dosage
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / genetics*
  • Spatio-Temporal Analysis

Substances

  • Antibiotics, Antineoplastic
  • BCL2 protein, human
  • Calcium Phosphates
  • Drug Combinations
  • Nanocapsules
  • Proto-Oncogene Proteins c-bcl-2
  • RNA, Small Interfering
  • Epirubicin
  • calcium phosphate